Online Process State Estimation for Hansenula polymorpha Cultivation with 2D Fluorescence Spectra-Based Chemometric Model Calibrated from a Theoretical Model in Place of Offline Measurements
The use of 2D fluorescence spectra is a powerful, instantaneous, and highly accurate method click here to estimate the state of bioprocesses.The conventional approach for calibrating a chemometric model from raw spectra needs a large number of offline measurements from numerous runs, which is tedious, time-consuming, and error-prone.In addition, ma