ONLINE PROCESS STATE ESTIMATION FOR HANSENULA POLYMORPHA CULTIVATION WITH 2D FLUORESCENCE SPECTRA-BASED CHEMOMETRIC MODEL CALIBRATED FROM A THEORETICAL MODEL IN PLACE OF OFFLINE MEASUREMENTS

Online Process State Estimation for Hansenula polymorpha Cultivation with 2D Fluorescence Spectra-Based Chemometric Model Calibrated from a Theoretical Model in Place of Offline Measurements

The use of 2D fluorescence spectra is a powerful, instantaneous, and highly accurate method click here to estimate the state of bioprocesses.The conventional approach for calibrating a chemometric model from raw spectra needs a large number of offline measurements from numerous runs, which is tedious, time-consuming, and error-prone.In addition, ma

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